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Question 1/101/10
Basic Knowledge in Pharmaceutical Chemistry - Chemistry of Drugs
Basic Knowledge in Pharmaceutical Chemistry - Chemistry of Drugs
Basic Knowledge in Pharmaceutical Chemistry - Chemistry of Drugs
A weakly basic drug is more likely to be absorbed in the stomach when it is in the unionized form because that form crosses lipid membranes more readily. Which change would generally increase its unionized fraction in gastric fluid?
Select the answer:Select the answer
1 correct answer
A.
Lowering the pH of the medium
B.
Raising the pH of the medium
C.
Increasing the ionic strength only
D.
Adding more water without changing pH
Weak bases become more unionized as pH rises above their pKa, so a higher pH favors the free base form and membrane permeation. Lowering pH does the opposite by increasing protonation.
Right Answer: B
Quiz
Question 2/102/10
Manufacturing of Pharmaceutical Dosage Forms
Manufacturing of Pharmaceutical Dosage Forms
Manufacturing of Pharmaceutical Dosage Forms
During tablet compression, a batch shows capping after prolonged storage of granules. Which adjustment is most likely to reduce this defect?
Select the answer:Select the answer
1 correct answer
A.
Increase the lubricant level substantially
B.
Reduce the moisture content to zero
C.
Improve granule binding and optimize compression conditions
D.
Use a larger particle size only
Capping is often linked to poor bonding, trapped air, or unsuitable compression conditions. Improving granule binding and adjusting compression parameters addresses the root cause more directly than simply increasing lubricant or eliminating all moisture.
Right Answer: C
Quiz
Question 3/103/10
Evaluation of Pharmaceutical Dosage Forms
Evaluation of Pharmaceutical Dosage Forms
Evaluation of Pharmaceutical Dosage Forms
A batch of tablets shows large variation in weight, but the assay of individual tablets is within limits. Which evaluation result is most directly affected?
Select the answer:Select the answer
1 correct answer
A.
Content uniformity
B.
Friability
C.
Disintegration time
D.
Hardness
Large unit-to-unit weight variation raises concern about dose consistency between tablets, which is assessed by content uniformity. Friability, hardness, and disintegration are different quality attributes and are not the primary test for this issue.
Right Answer: A
Quiz
Question 4/104/10
Basic Knowledge in Pharmaceutical Chemistry - Pharmacological Effects of Drugs
Basic Knowledge in Pharmaceutical Chemistry - Pharmacological Effects of Drugs
Basic Knowledge in Pharmaceutical Chemistry - Pharmacological Effects of Drugs
A patient takes a drug that lowers blood pressure by reducing peripheral vascular resistance. Which pharmacological effect best describes this action?
Select the answer:Select the answer
1 correct answer
A.
Positive inotropic effect
B.
Vasodilator effect
C.
Bronchoconstrictor effect
D.
Diuretic effect
Reducing peripheral vascular resistance is the hallmark of vasodilation. Positive inotropy affects cardiac contractility, diuresis affects urine output, and bronchoconstriction affects airway caliber.
Right Answer: B
Quiz
Question 5/105/10
Basic Knowledge in Pharmaceutical Chemistry - Toxicological Effects of Drugs
Basic Knowledge in Pharmaceutical Chemistry - Toxicological Effects of Drugs
Basic Knowledge in Pharmaceutical Chemistry - Toxicological Effects of Drugs
A patient taking isoniazid develops peripheral neuropathy after several weeks of therapy. Which measure best reduces this adverse effect without reducing the anti-tubercular benefit?
Select the answer:Select the answer
1 correct answer
A.
Add pyridoxine supplementation
B.
Switch to rifampicin monotherapy
C.
Increase the isoniazid dose
D.
Add calcium carbonate
Isoniazid can cause pyridoxine deficiency and peripheral neuropathy. Pyridoxine supplementation prevents or reduces this toxicity while allowing treatment to continue.
Right Answer: A
Quiz
Question 6/106/10
Basic Knowledge in Pharmaceutical Chemistry - Uses of Drugs
Basic Knowledge in Pharmaceutical Chemistry - Uses of Drugs
Basic Knowledge in Pharmaceutical Chemistry - Uses of Drugs
A patient with hypertension and angina is prescribed a drug that lowers blood pressure and also reduces the heart's oxygen demand. Which class best fits this use?
Select the answer:Select the answer
1 correct answer
A.
Antihypertensive beta blocker
B.
Antacid
C.
Expectorant
D.
Antifungal
Beta blockers are commonly used in hypertension and angina because they reduce heart rate, contractility, and oxygen demand, helping both conditions.
Right Answer: A
Quiz
Question 7/107/10
Basic Knowledge in Pharmaceutical Chemistry - Chemistry of Drugs
Basic Knowledge in Pharmaceutical Chemistry - Chemistry of Drugs
Basic Knowledge in Pharmaceutical Chemistry - Chemistry of Drugs
A pharmacist compares two salts of the same drug and notes that one dissolves faster in water but may be less stable on storage. The most likely reason is that the salt form has changed the drug's
Select the answer:Select the answer
1 correct answer
A.
molecular weight only
B.
ionization and solubility behavior
C.
chromophore and fluorescence only
D.
stereochemical configuration
Salt formation commonly alters ionization, solubility, and sometimes stability. It does not usually change the drug's stereochemistry or chromophore by itself.
Right Answer: B
Quiz
Question 8/108/10
Manufacturing of Pharmaceutical Dosage Forms
Manufacturing of Pharmaceutical Dosage Forms
Manufacturing of Pharmaceutical Dosage Forms
A pharmacist is preparing an oral solution of a drug that is poorly soluble in water. Which approach is most appropriate when the goal is to keep the drug in true solution rather than suspension?
Select the answer:Select the answer
1 correct answer
A.
Use a solubilizing agent or cosolvent system
B.
Increase the particle size of the drug
C.
Add a disintegrant to the vehicle
D.
Compress the solution into tablets
Poorly soluble drugs can be kept in true solution by using solubilizers, cosolvents, or related techniques. Increasing particle size or adding a disintegrant does not improve solubility in a liquid dosage form.
Right Answer: A
Quiz
Question 9/109/10
Evaluation of Pharmaceutical Dosage Forms
Evaluation of Pharmaceutical Dosage Forms
Evaluation of Pharmaceutical Dosage Forms
During quality control, a tablet sample loses 0.8% of its mass after the friability test. How should this result be interpreted for an uncoated tablet?
Select the answer:Select the answer
1 correct answer
A.
It clearly fails because any loss is unacceptable
B.
It generally passes because the loss is within the usual acceptable limit
C.
It fails only if the tablets are sugar-coated
D.
It cannot be interpreted without dissolution data
Friability measures resistance to abrasion, and uncoated tablets are commonly considered acceptable when weight loss is not more than about 1%. A 0.8% loss is therefore generally acceptable.
Right Answer: B
Quiz
Question 10/1010/10
Basic Knowledge in Pharmaceutical Chemistry - Pharmacological Effects of Drugs
Basic Knowledge in Pharmaceutical Chemistry - Pharmacological Effects of Drugs
Basic Knowledge in Pharmaceutical Chemistry - Pharmacological Effects of Drugs
In a hypertensive emergency, a medicine produces a rapid fall in arterial pressure mainly by relaxing vascular smooth muscle. The most direct effect is on the
Select the answer:Select the answer
1 correct answer
A.
Renal filtration rate
B.
Tone of arteriolar smooth muscle
C.
Rate of gastric emptying
D.
Synthesis of clotting factors
Arteriolar smooth muscle tone determines peripheral resistance and blood pressure. A rapid antihypertensive vasodilator acts primarily there, not on gastric emptying or clotting factor synthesis.
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Info quiz:
Quiz name:Mock Tests - UPSC Drug Inspector
Total number of questions:1217
Number of questions for the test:50
Pass score:70%
Number of topics:6 Topics
Study topics:Number of questions:
Basic Knowledge in Pharmaceutical Chemistry - Chemistry of Drugs:218 Questions
Basic Knowledge in Pharmaceutical Chemistry - Pharmacological Effects of Drugs:221 Questions
Basic Knowledge in Pharmaceutical Chemistry - Toxicological Effects of Drugs:244 Questions
Basic Knowledge in Pharmaceutical Chemistry - Uses of Drugs:137 Questions
Evaluation of Pharmaceutical Dosage Forms:197 Questions
Manufacturing of Pharmaceutical Dosage Forms:200 Questions
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